Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 62,225 articles • Showing 2 of 62,225
pubmed

PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression.

Druker J; Jiang H; Shakir D; Child F; Alvarez V; Platani M; Corno A; Alabert C; Saurin AT; Swedlow JR; Rocha S; Lamond AI

Scientists discovered a special way to look at a tiny part of proteins that helps cells divide correctly. They found out that an important protein, RepoMan, needs a little change at one spot to work properly with other cell parts. If this change doesn't happen, cells can have problems dividing and may even die.

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pubmed

Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry.

Jiang H; Druker J; Wilson JW; Bensaddek D; Swedlow JR; Rocha S; Lamond AI

The researchers created a new method to find special parts in proteins called proline hydroxylation sites. They used a special type of testing to find these sites in two different cell types. Some of these sites are important for things the cells do, like handling RNA and controlling when cells grow.

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