Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model.
Chen F; Saqib M; Nguyen CM; Sarver DC; Yu YE; Aja S; Seldin MM; Wong GW
Scientists studied mice with a genetic change like in people with Down syndrome to understand their metabolism problems. They found that both boy and girl mice had trouble with insulin, glucose, and fats. This study helps learn about Down syndrome metabolism and might help find new treatments.