Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 68,773 articles • Showing 2 of 68,773
pubmed

Molidustat Targets a Weakness in APC-Mutant Colorectal Cancer by Blocking GSTP1 and PHD2

Asselborn C; Makar AN; Marques Junior JG; Akan AB; Yiapanas A; Jennings C; Perez-Lopez A; Wills J; Unciti-Broceta A; Myant KB; von Kriegsheim A

Scientists found that a drug called Molidustat can kill some colon cancer cells with APC mutations. It seems to work by hitting another protein called GSTP1, not just its main target, and this may make the cancer cells stop growing and die.

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pubmed

Designing New Small Protein Inhibitors of Bacterial Adhesins

Chazin-Gray AM; Thompson TR; Lopatto EDB; Magala P; Erickson PW; Hunt AC; Manchenko A; Aprikian P; Tchesnokova V; Basova I; Sanick DA; Tamadonfar KO; Timm MR; Pinkner JS; Dodson KW; Kang A; Joyce E; Bera AK; Schmitz AJ; Ellebedy AH; Hvorecny KL; Interlandi G; Cartwright MJ; Vernet A; Bardales S; White D; Klevit RE; Sokurenko EV; Hultgren SJ; Baker D

Scientists made new tiny proteins that can stick to harmful bacteria and block them from causing infections. These proteins stopped bacteria from grabbing onto body cells, forming biofilms, and helped prevent and treat bladder infections in mice.

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