Research Articles

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Total: 52,696 articles • Showing 2 of 52,696
pubmed

UV irradiation alters TFAM binding specificity and compaction of DNA.

King DE; Beard EE; Satusky MJ; George A; Ryde I; Johnson C; Dolan EL; Zhang Y; Zhu W; Wilkins H; Corden E; Murphy SK; Erie DA; Gordân R; Meyer J

The researchers studied how a protein called TFAM helps protect parts of cells called mitochondria from damage. They found that TFAM binds differently to damaged DNA and helps pack it tightly, but it doesn't stop damage from happening. This suggests TFAM might sense damage and help control it in a way that prevents it from getting worse.

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pubmed

Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in .

Raices M; Balmir F; Silva N; Li W; Grundy MK; Hoffman DK; Altendorfer E; Camacho CJ; Bernstein KA; Colaiacovo MP; Yanowitz JL

During the creation of sperm and egg cells, breaks in the DNA called double-strand breaks (DSBs) are formed to help mix up genetic material. A special enzyme, Spo11, and other helper proteins control these breaks to make sure they happen in the right way. This research looked at how these proteins work together in tiny animals called nematodes, especially focusing on a protein called HIM-5 that helps repair the breaks on the X chromosome.

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