Research Articles

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Total: 67,462 articles • Showing 2 of 67,462
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How Auranofin May Help Fight Artery Disease

Amadori L; Calcagno C; Kaur R; Horstmann H; He T; Gildea M; Sakurai K; Chong PS; Shamailova R; Naidu S; Hill CA; Sajja S; Bresciani J; La Forest M; Ghotbi AA; Soler R; Faries C; Fisher EA; Fayad ZA; Fillmore NR; Ramos-Cejudo J; Readhead B; Dudley JT; Bjorkegren JLM; Giannarelli C

Scientists studied how special networks in our genes can help understand heart disease better and find new medicines. They found that a drug called auranofin, typically used for arthritis, might help reduce heart problems and inflammation. Their research showed promising results in both animals and people, suggesting this drug could be used in new ways to treat heart disease.

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Role of SLC4A7/NBCn1 in Regulating Cell pH and Immune Cell Function

Hu K; Wang YH; Tao AY; McDermott M; Jishage M; Zhong L; Boehringer T; Hines MJ; Koralov SB; Boedtkjer E; Feske S

This study looks at how a certain protein, called SLC4A7, helps special immune cells make antibodies. Without this protein, the cells can’t work well, especially when the body’s pH level changes. The researchers found that helping another part of the cell, mTORC1, can make up for this and help the immune cells do their job again.

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