Research Articles

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Total: 52,697 articles • Showing 2 of 52,697
pubmed

Redox robustness drives LPMO evolution.

Ayuso-Fernández I; Emrich-Mills TZ; Golten O; Forsberg Z; Hall KR; Nagy LG; Sørlie M; Kjendseth Røhr Å; Eijsink VGH

Scientists studied special enzymes called LPMOs that break tough plant materials and found they got better over time at handling powerful reactions without getting damaged. They used ancient versions of the enzymes to understand how they evolved and found that changes in the enzyme's structure helped them become more stable and strong.

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UV irradiation alters TFAM binding specificity and compaction of DNA.

King DE; Beard EE; Satusky MJ; George A; Ryde I; Johnson C; Dolan EL; Zhang Y; Zhu W; Wilkins H; Corden E; Murphy SK; Erie DA; Gordân R; Meyer J

The researchers studied how a protein called TFAM helps protect parts of cells called mitochondria from damage. They found that TFAM binds differently to damaged DNA and helps pack it tightly, but it doesn't stop damage from happening. This suggests TFAM might sense damage and help control it in a way that prevents it from getting worse.

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