Fully computational design of PAM-relaxed Cas9 with expanded targeting capability using UniDesign.
Xiong Y; Tsai LK; Zhou J; Chen S; Xia X; Zhang J; Chen YE; Xu J; Huang X
Scientists have made a new version of the CRISPR tool, called KRH, that can work on more DNA sites to change genes. This KRH version works better than the old version because it can recognize more DNA patterns. They made KRH using computer models to figure out which changes to make, without needing extra experiments.