Research Articles

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Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.

Liu BX; Zhou L; Lai S; Han X; Dai XJ; Liu R; Wang Y; Chen D; Wei J; Hu H; Zu W; Jiang L; Chang J; Zha L

Extrachromosomal DNA (ecDNA) helps cancer grow and change quickly by doing things that regular chromosomal DNA cannot. It can change how genes are used and even make cancer cells more resistant to treatments. Scientists are learning how this works, which might help create better cancer treatments in the future.

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Sugar-rich foods exacerbate antibiotic-induced microbiome disruption.

Dai A; Ballweg A; Jogia W; Rangesa M; Adintori PA; Baichoo M; Funnell T; Fei T; Waters NR; Swartz A; Sahu S; Gipson B; Raj SS; Hayase E; Pierce Z; Wu K; Smith N; Neuberger J; Warren A; da Silva MB; Miltiadous O; Zuanelli Brambilla C; Buchan ML; Peets TK; Gradissimo A; Amoretti LA; Duan C; Zhang C; Matheis F; Sullivan AP; Slingerland JB; Clurman AG; Brereton DG; Giardina PA; Gomes ALC; Johnson AJ; Knights D; Jenq RR; Markey KA; Perales MA; Giralt SA; van den Brink MRM; Schluter J; Peled JU

Researchers studied how diet affects gut bacteria in people receiving certain medical treatments. They found that eating a lot of sweets can make gut bacteria problems worse when taking antibiotics. Avoiding sugary foods might help keep gut bacteria healthy during treatment.

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