Research Articles

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Total: 65,302 articles • Showing 2 of 65,302
pubmed

How Parkinson's Disease Leads to Nerve Cell Damage in the Brain

Ghezzi L; Kuenen S; Pech U; Schoovaerts N; Kilic A; Poovathingal S; Davie K; Lamote J; Praschberger R; Verstreken P

Parkinson's disease happens when certain brain cells die, but other cells get affected before this happens. Scientists discovered that special cells called ensheathing glia, which are like oligodendrocytes, start acting differently early in the disease. By changing two specific genes, they found a way to help protect brain cells and possibly stop some damage from happening.

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pubmed

How Polycomb Modifications Start Spreading During Early Embryo Development

Gonzaga-Saavedra N; Degen EA; Soluri IV; Croslyn C; Blythe SA

Researchers studied how certain changes in DNA, called Polycomb modifications, happen in early embryos. They found that these changes start at specific spots in DNA, growing and spreading as the embryo develops. They also discovered that some proteins usually needed for these changes aren't important, while another protein, Zelda, helps some parts of these changes happen correctly.

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