Research Articles

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Total: 55,117 articles • Showing 2 of 55,117
pubmed

Fully computational design of PAM-relaxed Cas9 with expanded targeting capability using UniDesign.

Xiong Y; Tsai LK; Zhou J; Chen S; Xia X; Zhang J; Chen YE; Xu J; Huang X

Scientists have made a new version of the CRISPR tool, called KRH, that can work on more DNA sites to change genes. This KRH version works better than the old version because it can recognize more DNA patterns. They made KRH using computer models to figure out which changes to make, without needing extra experiments.

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pubmed

Dynamic architecture of mycobacterial outer membranes revealed by all-atom simulations.

Brown TP; Chavent M; Im W

The research is about tuberculosis germs having strong outer layers that make them hard to treat with medicines. Scientists used computer models to study these layers and found that certain parts help the germs stay strong and protect them from medicines. This information can help make new medicines to fight these germs.

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