Research Articles

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Total: 65,167 articles • Showing 2 of 65,167
pubmed

Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia.

Datta A; Dewan P; Puthoor AA; Chhabra T; Tejaswi T; Muthukrishnan S; Rao A; Sarkar S; Vishwakarma M

The study explains why a cancer change happens in some body parts but not others. They found that how cells push or pull on each other affects if a cell becomes cancerous in different body tissues. The way these cells act is different, like in breast and lung cells, which helps us understand how cancer might start or grow.

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pubmed

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics.

Tombesi G; Kompella S; Favetta G; Chen C; Ornaghi M; Zhao Y; Morosin E; Sevegnani M; Lama A; Marte A; Battisti I; Iannotta L; Plotegher N; Civiero L; Onofri F; Eickholt BJ; Piccoli G; Arrigoni G; Beccano-Kelly D; Manzoni C; Parisiadou L; Greggio E

Scientists have found that an important protein called LRRK2 is involved in changes in brain cells that may lead to Parkinson's disease. They studied how this protein works with other parts of the cell in mice and human-like cells and noticed that problems with LRRK2 can affect how brain cells talk to each other. These changes could happen years before other signs of Parkinson's disease appear.

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