Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 68,547 articles • Showing 2 of 68,547
pubmed

Estimating bone marrow adiposity from head MRI and identifying its genetic architecture.

Kaufmann T; Bjørnstad PM; Falck M; Nerland S; O'Connell K; Frei O; Andreassen OA; Westlye LT; Djurovic S; Hughes T

Scientists studied fat in the bone marrow of the skull using brain MRI scans and a computer model. They found that this fat changes with age, differs between males and females, and is partly controlled by genes. They also found links between this trait and things like thinking skills and Parkinson’s disease.

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Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer.

Wang Q; Li L; You L; Wang S; Han L; Wang B; Yao L; Addepalli Y; Lu Y; Mender I; Flusche AM; Kim C; Yarravarapu N; Lemoff A; Lum L; Shay JW; Yu Y; Chen C

Scientists found that a cancer-driving signal called WNT/beta-catenin can be hard to block in colon cancer. Drugs that only block one tankyrase function can cause clumps that stop the treatment from working well, but removing tankyrase instead may work better and slow cancer cell growth.

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