pubmed
Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced mechanical pain hypersensitivity.
Kawanabe-Kobayashi R; Uchiyama S; Yoshihara K; Koga K; Kojima D; McHugh TJ; Hatada I; Matsui K; Tanaka KF; Tsuda M
Scientists found that stress can make pain worse by affecting certain nerve cells and special brain cells called astrocytes in mice. These activated astrocytes talk to nerves that usually help stop pain, but when these talks are interrupted, pain feels worse. Knocking out certain signals in these cells can help reduce the stress-related pain.
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