Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.
Goh KY; Lee WX; Gou Q; Choy SM; Ong SC; Gopal Krishnan PD; Wang H; Turqueza LRR; Tan QH; Chua K; Li S; Nishiyama J; Harmston N; Tang HW
Muscles help stop tumors from growing by sending out tiny particles called EVs. As people get older, their muscles send out fewer EVs, which makes it easier for tumors to grow. Exercise can help older muscles send out more EVs again.