Scientists are studying how cells use their shapes to organize themselves and react to different forces. They created new math tools to help understand cell shapes better. This helps them see how cells behave in groups and learn more about how tissues work and grow.
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The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
Suryawanshi RK; Jaishankar P; Correy GJ; Rachman MM; O'Leary PC; Taha TY; Matsui Y; Zapatero-Belinchón FJ; McCavitt-Malvido M; Doruk YU; Stevens MGV; Diolaiti ME; Jogalekar MP; Chen H; Richards AL; Kongpracha P; Bali S; Montano M; Rosecrans J; Matthay M; Togo T; Gonciarz RL; Gopalkrishnan S; Neitz RJ; Krogan NJ; Swaney DL; Shoichet BK; Ott M; Renslo AR; Ashworth A; Fraser JS
Scientists discovered a new small molecule called AVI-4206 that helps fight the virus causing COVID-19 by boosting the body's immune response. Tests showed that AVI-4206 works well in stopping the virus in different models, and helps animals survive severe infections. This new method might be used to create more virus-fighting medicines in the future.
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