Research Articles

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Total: 60,714 articles • Showing 2 of 60,714
pubmed

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.

Bayanjargal A; Taslim C; Showpnil IA; Selich-Anderson J; Crow JC; Zhou R; Lessnick SL; Theisen ER

Ewing sarcoma is a type of bone cancer that mainly affects kids and young adults. Most patients have a change in their DNA causing the EWSR1::FLI1 protein, which helps the cancer grow. The study showed that a part of this protein called the DBD-α4 helix is very important for the cancer to spread because it helps the protein stick to certain DNA parts and control how genes work.

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pubmed

Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.

Parrotta E; Bach P; Pezzulo G; Zaccaro A; Perrucci MG; Costantini M; Ferri F

Scientists studied how our hearts and brains can affect how much pain we feel. They found that by making people think their hearts were beating faster, they expected more pain, and then felt stronger pain and showed changes in heart rate. This shows how our mind can change how we feel and react to pain.

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