Research Articles

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Total: 39,853 articles • Showing 2 of 39,853
pubmed

Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer's disease.

van Adrichem JJ; van der Loo RJ; Ambrosini Defendi R; Smit AB; van den Oever MC; van Kesteren RE

The study found that mice with Alzheimer's disease lose older memories as they age because certain brain cells become too excited. This excitement makes it hard for important memory cells to work properly, which contributes to more memory loss.

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pubmed

Hierarchical Bayesian modeling of multiregion brain cell count data.

Dimmock S; Exley BMS; Moore G; Menage L; Delogu A; Schultz SR; Warburton EC; Houghton CJ; O'Donnell C

Scientists can now study whole animal brains after the animal has died to learn about brain activity and connections. This research is hard because each animal only gives one set of information, and it takes a lot of time and money. A new model using Bayesian methods helps researchers understand their data better than older methods.

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