The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.
Bayanjargal A; Taslim C; Showpnil IA; Selich-Anderson J; Crow JC; Zhou R; Lessnick SL; Theisen ER
Ewing sarcoma is a type of bone cancer that mainly affects kids and young adults. Most patients have a change in their DNA causing the EWSR1::FLI1 protein, which helps the cancer grow. The study showed that a part of this protein called the DBD-α4 helix is very important for the cancer to spread because it helps the protein stick to certain DNA parts and control how genes work.