Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast accumulation by inhibiting Parkin-dependent mitophagy.
Nie Y; Xu L; Liu Y; Li J; Wang Z; Zhai X; Sun X; Hu C; Xu B; Wu Y; Yu H; Karpurapu M; Guo H; Chai G
The study looked at a lung problem called idiopathic pulmonary fibrosis. Scientists found that a protein called Hdac11 is higher in sick lungs and makes the disease worse. By stopping this protein, they can help slow down the sickness.