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pubmed

Multimodal substrate recruitment enables CTLH E3 ligase to target acetylated N-, C-, and internal degrons.

Sepic S; Gottemukkala KV; Du J; Maiwald SA; Chrustowicz J; Papadopoulou EC; Stier LJ; von Gronau S; Schulman BA

The research explores how a protein called MKLN1 works with other proteins to help break down certain molecules. MKLN1 has special parts that help it grab onto different partners, using its discoidin and Kelch domains. This helps MKLN1 recognize and manage different molecules in unique ways.

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pubmed

cPRIME Helps Study How Genetic Variants Affect RNA

El Kassem G; Westphal C; Doebel M; Hillmer J; Seifert T; Boettcher M

Scientists have a new tool called cPRIME to study how changes in genes affect RNA, which helps them understand diseases better. They found that even small changes used in experiments might change how RNA works, so this tool helps them find these effects more accurately.

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