IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2.
Zhang P; Wu W; Huang T; Wu X; Wang D; Yuan H; Taori S; Yuan F; Vendetti FP; Wang R; Duan T; Mi H; Li H; Yang K; Li D; Habib A; Prager BC; Gimple RC; Zinn PO; Abdullah K; Bakkenist C; Zhang J; Wu Q; Rich JN
Cancer cells can become harder to treat when their surroundings are stiff. In brain cancer, a protein called IQGAP3 helps cancer cells survive radiation by holding onto another protein, SOX2. By stopping IQGAP3, a drug called trimetrexate helps make the cancer cells more sensitive to radiation.