How LRRK2 Protein Affects Nerve Cell Connections by Changing Cell Skeleton Structures
Tombesi G; Kompella S; Favetta G; Chen C; Ornaghi M; Zhao Y; Morosin E; Sevegnani M; Lama A; Marte A; Battisti I; Iannotta L; Plotegher N; Civiero L; Onofri F; Eickholt BJ; Piccoli G; Arrigoni G; Beccano-Kelly D; Manzoni C; Parisiadou L; Greggio E
Scientists have found that an important protein called LRRK2 is involved in changes in brain cells that may lead to Parkinson's disease. They studied how this protein works with other parts of the cell in mice and human-like cells and noticed that problems with LRRK2 can affect how brain cells talk to each other. These changes could happen years before other signs of Parkinson's disease appear.