A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival.
Chen L; Duan B; Chen P; Jiang Q; Wang Y; Lu L; Chen Y; Hu C; Zhang L; Guo A
Scientists discovered a protein called MgdE in bacteria that helps them survive inside host cells. MgdE moves into the nucleus of the host cell and interferes with certain proteins, which stops some important processes that usually fight infections. This helps the bacteria to live longer inside the body.