Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to infection.
Matteucci KC; Leite NPS; Assis PA; Hirako IC; Pioto F; Ojelabi O; Toller-Kawahisa JE; Vaz LG; Costa DL; da Silva JS; Alves-Filho JC; Gazzinelli RT
The study found that TNF helps the body fight infections by controlling energy and sugar use, but it also makes mice feel sick and less active. TNF is needed for special cells in the body to work properly and fight off infections.