Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 50,784 articles • Showing 2 of 50,784
pubmed

Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.

Rajagopal VM; Ziyatdinov A; Joseph T; Ayer A; Ahmed M; Mbatchou J; Zou Y; Averitt AJ; Banerjee N; Cantor M; Torres JM; Chen E; Varela JR; Jones M; Overton J; Harari O; Lotta L; Abecasis G; Baras A; Berumen J; Kuri-Morales P; Alegre-Díaz J; Tapia-Conyer R; Collins R; Emberson JR; Marchini J; Coppola G

Scientists studied a gene called CHRNB3, linked to how much people smoke, in different groups of people. They found certain changes in this gene that might help people smoke less. These changes could help make new medicines to fight smoking addiction.

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pubmed

Combination of PARP and KRAS inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC.

Xu X; Chen X; Xu R; Huo Z; Li C; Nowsheen S; Aziz K; Yao F; Lou Z; Deng M

Researchers found that a new treatment combination could help fight a type of pancreatic cancer. The treatment targets a gene called KRAS and makes the cancer cells more sensitive to another type of medicine. This approach helps stop the cancer and boosts the body's immune response.

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