Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 58,461 articles • Showing 2 of 58,461
pubmed

Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein.

Han Z; Panhans S; Brameyer S; Bilgen E; Ram M; Herr A; Narducci A; Isselstein M; Harris PD; Brix O; Con P; Jung K; Lamb DC; Lerner E; Griffith D; Weikl TR; Zijlstra N; Cordes T

Scientists studied how a protein called GlnBP helps cells take in amino acids. They found out that the protein changes shape after it grabs onto a molecule, which fits the idea of an "induced-fit" model. They also think other proteins should be studied more to understand them better.

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pubmed

Multimodal sequencing identifies synergistic mechanisms driving resistance to neoadjuvant nivolumab treatment in hepatocellular carcinoma.

Zeng F; Guo J; Zeng Z; Zhang VX; Tsui YM; Li PM; Husain A; Zhang Q; Lee JM; Cheung TT; Ho DW; Ng IO

Researchers studied liver cancer and found that tumors can block medicine that helps the immune system fight the cancer. They discovered that some patients' tumors make it hard for immune cells to get inside because of certain fat-related changes and special signals between tumor cells and immune cells. This helps explain why some treatments don't work as well and could help find new ways to treat the cancer.

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