Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.
Papadopoli D; Palia R; Jovanovic P; Tabariès S; Ciccolini E; Sabourin V; Igelmann S; McLaughlan S; Zhan L; Kim H; Chekkal N; Szkop KJ; Bertomeu T; Zeng J; Vassalakis J; Afzali F; Mzoughi S; Guccione E; Tyers M; Avizonis D; Larsson O; Postovit LM; Djuranovic S; Ursini-Siegel J; Siegel PM; Pollak M; Topisirovic I
Researchers found that when cells don't have enough of a protein called ETF, it can cause serious health problems, except in certain cancer cells. In cancer, less ETF can actually help the cancer grow faster. This happens because it changes how the cells get their energy.