pubmed
A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution.
Spokaite S; Ohashi Y; Bourguet M; Dessus AN; Williams RL
Scientists discovered that a protein complex named VPS34 helps cells manage recycling and disposal of materials, using proteins called RAB5 and VPS15. They found the structure of this complex and learned how different parts of it work together to help do this important job in cells. They also learned that changes to certain parts can affect how well the complex works.
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