How Overactive Cell Signaling Leads to Aortic Problems in Marfan Syndrome
Alarcón-Ruiz I; Ruiz-Rodríguez MJ; Martínez-Martínez S; Toral M; Martín-Bermejo N; Mateos-García S; Gil-Ruiz T; Herrero-Galán E; Méndez-Olivares MJ; López-Maderuelo D; Gutiérrez-Martínez C; Clemente C; Clemente-Manteca A; H-Alcántara A; Guala A; Evangelista A; Teixido-Tura G; Rodríguez-Puyol D; Nistal JF; Alegre-Cebollada J; Vázquez J; Duarte J; Redondo JM; Campanero MR
Researchers discovered a new way that leads to problems in the heart called aortic disease in people with Marfan syndrome. They found that a sticky protein called fibronectin builds up and starts a process that ends in disease, but stopping this process can help. This finding could help develop new treatments for Marfan syndrome.