Modeling CIC::DUX4 sarcoma reveals oncogene-mediated MHCI-dependent immune evasion.
Vachanaram AR; Wei E; Mitanoska A; Bassett W; Kyba M; Bosnakovski D
Researchers created a special mouse model to study a type of cancer called CIC::DUX4 sarcoma. This model helps them understand how the cancer grows, how it avoids the immune system, and ways to stop it using new treatments. They found that stopping a specific protein or using certain drugs can help the immune system fight the cancer better.