How the DNMT1 CXXC Domain Detects DNA Regions to Prevent Methylation
Fang J; Pan B; Ren W; Lu J; Zhao T; Guo Y; Cai L; Wang Y; Wang GG; Song J
DNA methyltransferase DNMT1 helps keep the DNA's instructions stable. Scientists found out that a part of DNMT1, called the CXXC domain, stops it from adding too many markers on certain DNA parts called CpG islands. This helps keep DNA instructions right, which is very important for growing cells.