Research Articles

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pubmed

Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G.

Rajagopalan S; Chiu J; Chaurasia P; Lu J; Mastorakos GM; Majumder S; Nolan KT; Petersen J; Adams EJ; Sun PD; Rossjohn J; Hogg PJ; Long EO

HLA-G is a special molecule on baby cells that helps them talk to the mother's immune cells. Scientists found out how a part of a cell called KIR2DL4 changes shape to do this. These changes help baby cells grow and develop by sending special signals.

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pubmed

How Differences in JAK-STAT Pathway Affect Breast Cancer Treatment Response

Zhou J; Zhang H; Tang H; Yu L; Peng F

Scientists found that a part of cells called the JAK-STAT pathway acts differently in breast cancer after a certain treatment. This pathway can help fight tumors in some cells but also make cancer worse in others, making it important to choose treatments carefully. It might be a useful sign to tell if some patients will do well with a specific cancer treatment.

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