Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids.
Roh JD; Bae M; Oh Y; Yang Y; Lee S; Hwang WC; Yang E; Kim H; Jang H; Choi HW; Kim H; Kim JY; Kim E
Scientists found a new way to help brain problems like autism and schizophrenia by using a special technique called ASO to change a glycine transporter in the brain. This method helps improve brain function in mice with certain gene mutations, and it may help people in the future too.