pubmed
Nonlinear transcriptional responses to gradual modulation of transcription factor dosage.
Domingo J; Minaeva M; Morris JA; Ghatan S; Ziosi M; Sanjana NE; Lappalainen T
The study looked at changing how much certain genes are turned on or off in cells to understand how this affects the cells and traits. They used a special tool to slowly change gene activity and found that adjusting this can change many other genes in surprising ways. This helps scientists learn more about how gene changes relate to diseases.
View Details