Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.
Patton ME; Kelekar S; Taylor LJ; Dean AE; Zuo Q; Thakare RN; Lee SH; Gentry EC; Panitchpakdi M; Dorrestein P; Alnouti Y; Madak-Erdogan Z; Lee JS; Finegold MJ; Anakk S
The study found that male mice have higher levels of a liver cancer similar to humans. Female mice are protected because of how their bodies handle certain substances differently. When females' protective factors were removed, they got more liver tumors too, and a medicine helped reduce liver cancer in male mice.