Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 56,714 articles • Showing 2 of 56,714
pubmed

Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.

Tetenborg S; Shihabeddin E; Kumar EOAM; Sigulinsky CL; Dedek K; Lin YP; Echeverry FA; Hoff H; Pereda AE; Jones BW; Ribelayga CP; Ebnet K; Matsuura K; O'Brien J

Scientists studied special connections in brain cells that help them communicate directly through electricity, focusing on a protein called Connexin 36. They found many new proteins that join with Connexin 36 to help it function, including one important protein called Sipa1l3. This research gives a better understanding of how these electrical connections work in the brain.

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pubmed

Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments.

Lövestam S; Wagstaff JL; Katsinelos T; Shi J; Freund SMV; Goedert M; Scheres SHW

Scientists have found a way to make tau proteins in the lab that look like the ones found in the brains of people with Alzheimer's disease. They made special changes to the tau protein that help it form these shapes, which will help them study brain diseases better.

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