Research Articles

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Total: 39,847 articles • Showing 2 of 39,847
pubmed

Cell line-matched reference enables high-precision functional genomics.

Corda L; Volpe E; Dallali H; Di Tommaso E; Colantoni A; Guarracino A; Chittoor SS; Capulli M; Tassone E; Giunta S

Scientists found that using a special type of genome, called an "isogenomic" diploid reference genome, can make studying and editing human cell DNA much better. They used it for a well-known cell line and discovered differences in DNA and other cell parts that were specific to certain haplotypes and chromosomes. This approach helps improve the accuracy of genetic studies and suggests that more cell lines should have their own custom genomes.

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pubmed

Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults.

Stanislawski MA; Litkowski E; Arehart CH; Luo K; Gilmore N; Lange LA; Lange EM; Barnes K; Avery CL; Meyer KA; Holguin F; North KE; Burk RD; Kaplan RC

This research looks at how gut bacteria might be linked to asthma in Hispanic/Latino adults. The study finds that certain gut bacteria differences are connected to asthma, and knowing about these bacteria can help understand asthma better, regardless of obesity. The findings suggest that gut bacteria information can improve figuring out who has asthma.

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