Research Articles

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Total: 47,653 articles • Showing 2 of 47,653
pubmed

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

Patton ME; Kelekar S; Taylor LJ; Dean AE; Zuo Q; Thakare RN; Lee SH; Gentry EC; Panitchpakdi M; Dorrestein P; Alnouti Y; Madak-Erdogan Z; Lee JS; Finegold MJ; Anakk S

The study found that male mice have higher levels of a liver cancer similar to humans. Female mice are protected because of how their bodies handle certain substances differently. When females' protective factors were removed, they got more liver tumors too, and a medicine helped reduce liver cancer in male mice.

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pubmed

ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility.

Yu S; Yin G; Jin P; Zhang W; Tian Y; Xu X; Shao T; Li Y; Sun F; Zhu Y; Wang F

A protein called ANKEF1 is important for sperm movement, which helps in having babies. When mice didn’t have this protein, their sperm didn't move well even though the energy levels were normal. This shows that ANKEF1 helps keep the sperm structure stable.

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