pubmed
De novo design of a macrocycle-induced dimerization system for cellular control.
Hanna S; Salveson PJ; Wicky B; Kennedy MA; Hicks DR; Moller C; Cheng S; Li X; Abedi M; Coventry B; Said MY; Bera AK; Kang A; Stoddard BL; Baker D
Scientists created a new tool to control how cells work by making special proteins and chemicals stick together. They designed a tiny ring-shaped molecule and a matching protein that fit together perfectly. This new system can help turn on or off cell activities, like a light switch for cell functions.
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