Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 68,468 articles • Showing 2 of 68,468
pubmed

Compensation of hyperexcitability with simulation-based inference.

Müller-Komorowska D; Fukai T

Healthy brain cell networks need to stay balanced, but if they become too active, they can cause problems like seizures and memory trouble. This study used computer simulations to find which changes in the network can help bring activity back to normal. It also showed that different causes of too much activity need different fixes.

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pubmed

SVEP1 enables efficient binding of angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling.

Uphoff K; Hußmann M; Peters O; Mörgelin M; Metzen F; Obermann WMJ; Bazan FJ; Stetefeld J; Koch M; Schulte-Merker S; Schulte-Ostermann D

Scientists found that two proteins, SVEP1 and TIE1, stick together in a way that may help form lymph vessels. They also found that another protein, ANG2, helps turn on TIE1 and send stronger signals inside cells.

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