Research Articles

Peer-reviewed studies distilled into actionable summaries. Updated daily.

Total: 69,035 articles • Showing 2 of 69,035
pubmed

IGF2BP3 helps esophageal cancer grow by promoting immune cell changes and stabilizing beta-catenin

Tian Z; Zhou Y; Zhao Y; Li P; Ding Y; Tang G; Zhao Y; Cui Q; Li P; Pedersen LB; Jiang N; Wu H; Zhao X

Esophageal squamous cell carcinoma is a very fast-growing cancer that is hard to treat. This study looked at a protein called IGF2BP3 to see how it helps the cancer grow and how it may affect the body’s immune response around the tumor.

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pubmed

Targeted RNA Interference for Fibrodysplasia Ossificans Progressiva in Mice Using a Combined Allele-Selective Approach

Yang YS; Gross KY; Cooper D; Chaugule S; Kim MJ; Dahlke C; Mayer E; Kercher EM; Kim JW; Ormsby T; Yamada N; Caiazzi J; Jackson SO; Rachid MO; Aronson BF; Echiverria D; Fakih HH; Yamada K; Lee FY; Khvorova A; Alterman JF; Shim JH

Scientists tested a new treatment that targets a harmful gene in a rare disease called fibrodysplasia ossificans progressiva. In mice, it lowered painful flare-ups and extra bone growth, and the best results came when it also blocked a second inflammation signal.

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