pubmed
Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling.
Hallinan C; Ji HJ; Tsou E; Salzberg SL; Fan J
Scientists studied how certain tools used to look at genes in specific areas can sometimes make mistakes by sticking to the wrong genes. They made a new tool called OPT to help find these mistakes and tested it on some gene samples. They found that a few genes were affected by this problem, and their tool helped understand and fix it to get more accurate results.
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